Human research · meta-analysis
Rahman E et al., BMJ Open 2026
A systematic review of randomised controlled trials (RCTs) found only 3 small, short trials of coenzyme Q10 (CoQ10) in heart failure with preserved ejection fraction (HFpEF) and concluded the evidence is insufficient to tell whether CoQ10 helps: deaths and heart-failure hospitalisations were too rare to analyse, and the one trial measuring quality of life gave conflicting results between its two comparisons. All primary-outcome evidence was rated very low certainty (GRADE). This is a null/uninformative review, not evidence of benefit or harm.
Source: Effectiveness and safety of coenzyme Q10 in people with heart failure with preserved ejection fraction (HFpEF): a systematic review and meta-analysis. Rahman E, Webster KE, Nightingale AK, Pufulete M. BMJ Open. 2026;16(10):e116033. doi:10.1136/bmjopen-2025-116033. PMID:42869600. PMCID:PMC13663742. Published 2026-10-13. Full text read (PMC)
Verified research card EL-20261018-05-R1