Human research · observational
Speichinger F et al., Journal of Cellular and Molecular Medicine 2026
In a small prospective biopsy study of peripheral artery disease (PAD) patients, calf-muscle mitochondrial respiration normalised to mitochondrial content changed 6 weeks after successful revascularisation in patients with intermittent claudication (a decline the authors read as normalisation), but showed no significant change in patients with chronic limb-threatening ischemia (CLTI), whose mitochondrial content marker (citrate synthase activity) rose. Observational, no control group, very small paired CLTI subgroups.
Source: Chronic Limb-Threatening Ischemia Shows No Adaptability of Mitochondrial Function After Revascularisation. Speichinger F, Gratl A, Raude B, Arndt M, Hering NA, Greiner A, Pesta D, Schineis C, Frese JP. Journal of Cellular and Molecular Medicine. 2026;30(20):e71383. doi:10.1111/jcmm.71383. PMID:42888834. First published 2026-10-16. Ethics EA4/139/16
Verified research card EL-20261018-02