In older adults with amnestic MCI, 12 weeks of nicotinamide riboside (1,000 mg/day) roughly doubled blood NAD+ but did not improve cognitive function (primary outcome), total cerebral blood flow or blood pressure vs placebo.
Source: A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment. Martens CR, Decker KP, DeConne TM, et al. Alzheimer's & Dementia. 2026;22(7):e71605. doi:10.1002/alz.71605
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